[1]夏 芳a,汪隆海a,方 超a,等.血清5种生物标志物水平联合检测对心力衰竭的诊断价值[J].现代检验医学杂志,2019,34(04):22-27.[doi:10.3969/j.issn.1671-7414.2019.04.006]
 XIA Fanga,WANG Long-haia,FANG Chaoa,et al.Combined Detection of Serum 5 Biomarkers for the Diagnostic Value of Heart Failure[J].Journal of Modern Laboratory Medicine,2019,34(04):22-27.[doi:10.3969/j.issn.1671-7414.2019.04.006]
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血清5种生物标志物水平联合检测对心力衰竭的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年04期
页码:
22-27
栏目:
论 著
出版日期:
2019-08-20

文章信息/Info

Title:
Combined Detection of Serum 5 Biomarkers for the Diagnostic Value of Heart Failure
文章编号:
1671-7414(2019)04-022-06
作者:
夏 芳1a汪隆海2a方 超1a张求霞2a黄 飞2a谷光敏1b王 勇2b程 刚1c宋 川2c
(1.安徽省含山县人民医院a.检验科; b.心内科; c.彩超室,安徽含山238100; 2.宋庆龄爱心医院a.检验科; b.心内科; c.彩超室,安徽巢湖 238000)
Author(s):
XIA Fang1aWANG Long-hai2aFANG Chao1aZHANG Qiu-xia2aHUANG Fei2a GU Guang-min1bWANG Yong2bCHENG Gang1cSONG Chuan2c
(1a.Department of Clinical Laboratory; 1b.Department ofCardiology; 1c.Room of Ultrasonic Diagnosis,the People's Hospital of Hanshan County,Anhui Hanshan 238100,China; 2a.Department of Clinical Laboratory; 2b.Department of Cardiology; 2c.Room of Ultrasonic Diagnosis,Song Qingling Caring Hospital,AnhuiChaohu 238000,China)
关键词:
生物标志物 心力衰竭 联合检测 诊断价值
分类号:
R541.6; R392.11
DOI:
10.3969/j.issn.1671-7414.2019.04.006
文献标志码:
A
摘要:
目的 评价血清5种生物标志物水平对心力衰竭(HF)患者的诊断价值。方法 采用化学发光法与定量ELISA改进法检测不同程度HF患者的血清5种生物标志物水平,运用IBM SPSS23.0与SAS 9.4软件对结果进行统计处理。结果 Ⅰ~Ⅳ级HF患者的血清5种生物标志物水平明显增高,N末端脑钠肽(NT-proBNP)、中段心房利钠肽原(MR-proANP)、大内皮素1(BigET-1)、和肽素(copeptin)与半乳糖凝集素-3(Gal-3)的结果分别为3.09±0.37,3.53±0.55,3.70±0.52和3.93±0.46 ng/L,2.50±0.27,3.01±0.60,3.21±0.58和3.43±0.63pmol/L,3.97±1.34,5.43±1.80,6.14±1.80和7.09±1.98 pmol/L,16.12±3.19,19.22±3.74,21.30±3.86和23.54±4.42 pmol/L,29.94±4.06,34.35±5.68,36.58±5.90和39.60±6.35 μg/L,差异均具有统计学意义(F=71.804128.045.P<0.000)。5种生物标志物的实验受试者特征曲线下面积分别为0.988 5,0.986 6,0.949 2,0.978 3和0.977 4,它们两两比较,9对有差别,1对无差别。用NT-proBNP≥719.5 ng/L,MR-proANP≥192.5 pmol/L,Big ET-1≥3.45 pmol/L,和肽素≥14.0 pmol/L与Gal-3≥27.15 μg/L来联合诊断HF患者,有2项符合即可诊断。敏感度为98.6%,特异度为98.2%,诊断符合率为98.5%。结论 联合检测血清5种生物标志物,能提高HF诊断的敏感度和特异度。

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相似文献/References:

[1]汪隆海a,陈启松b,夏 芳a,等.和肽素与大内皮素-1及N末端 脑钠肽对心力衰竭的预后价值[J].现代检验医学杂志,2015,30(01):64.[doi:10.3969/j.issn.1671-7414.2015.01.017]
 WANG Long-haia,CHEN Qi-songb,XIA Fanga,et al.Prognostic Value of Copeptin,Big Endothelin-1 and N-Terminal Pro-Brain Natriuretic Peptide in Patients with Chronic Heart Failure[J].Journal of Modern Laboratory Medicine,2015,30(04):64.[doi:10.3969/j.issn.1671-7414.2015.01.017]

备注/Memo

备注/Memo:
作者简介:夏 芳(1978-),女,硕士研究生,副主任检验师,从事临床生物化学检验与研究,E-mail:xiayueye1978@163.com。收稿日期:2019-05-05 修回日期:2019-05-20
更新日期/Last Update: 2019-07-30